Bệnh viêm nha chu tiềm ẩn nguy cơ gì ?
Bệnh viêm nha chu là căn bệnh rất phổ biến không chỉ ở việt
nam mà hầu hết các nước. Bệnh không gây nguy hiểm đến tính mạng nhưng việc điều
trị tận gốc là hết sức khó khăn. Nghiên cứu sau đây được thuốc tây đặc trị sưu
tầm còn chỉ ra một tiềm ẩn nguy hiểm khác của viêm nha chu. Hãy cùng tìm hiểu
xem
Bệnh nha chu hoặc bệnh nướu răng được biết đến là một yếu tố
nguy cơ đáng kể của hội chứng chuyển hóa, một nhóm bệnh làm tăng nguy cơ mắc bệnh
tim và bệnh tiểu đường. Trong một nghiên cứu mới, các nhà nghiên cứu từ Đại học Y
khoa và Nha khoa Tokyo (TMDU) đã phát hiện ra rằng nhiễm khuẩn Porphyromonas
gingivalis, vi khuẩn gây bệnh nha chu, gây rối loạn chức năng trao đổi chất ở
cơ xương, tiền thân của hội chứng chuyển hóa, bằng cách thay đổi thành phần của
hệ vi sinh vật đường ruột.
Vi khuẩn nha chu từ lâu đã được biết đến là nguyên nhân gây
viêm trong khoang miệng, nhưng cũng làm tăng hệ thống các chất trung gian gây
viêm. Kết quả là, nhiễm vi khuẩn nha chu kéo dài có thể dẫn đến tăng trọng lượng
cơ thể và dẫn đến tăng đề kháng insulin, một dấu hiệu của bệnh tiểu đường loại
2. Chức năng của insulin là giúp vận chuyển glucose từ máu vào các mô, quan trọng
nhất là đến cơ xương, nơi dự trữ một phần tư lượng glucose. Không có gì ngạc
nhiên khi đề kháng insulin đóng một vai trò quan trọng trong sự phát triển của
hội chứng chuyển hóa, một nhóm các tình trạng bao gồm béo phì, thay đổi chuyển
hóa lipid, huyết áp cao, mức đường huyết cao và viêm toàn thân. Mặc dù cơ xương
đóng một vai trò quan trọng trong việc giảm đường huyết,
Tác giả đầu tiên của nghiên cứu Kazuki Watanabe cho biết: “Hội
chứng chuyển hóa đã trở thành một vấn đề sức khỏe phổ biến ở các nước phát triển.
"Mục tiêu của nghiên cứu của chúng tôi là tìm hiểu cách thức nhiễm vi khuẩn
nha chu có thể dẫn đến những thay đổi chuyển hóa trong cơ xương và do đó dẫn đến
sự phát triển của hội chứng chuyển hóa."
Để đạt được mục tiêu của mình, các nhà nghiên cứu đầu tiên
đã điều tra hiệu giá kháng thể đối với gen Porphyromonas trong máu của bệnh
nhân mắc hội chứng chuyển hóa và tìm thấy mối tương quan thuận giữa hiệu giá
kháng thể và sự gia tăng đề kháng insulin. Những kết quả này cho thấy những bệnh
nhân mắc hội chứng chuyển hóa có khả năng đã từng bị nhiễm vi khuẩn
Porphyromonas gingivalis và do đó đã tạo ra phản ứng miễn dịch tạo ra kháng thể
chống lại vi trùng. Để hiểu cơ chế đằng sau quan sát lâm sàng, các nhà nghiên cứu
sau đó chuyển sang mô hình động vật. Khi họ cho những con chuột được cho ăn một
chế độ ăn giàu chất béo (điều kiện tiên quyết để phát triển hội chứng chuyển
hóa) Porphyromonas gingivalis bằng đường uống, những con chuột phát triển sự đề
kháng insulin tăng lên,
Nhưng làm thế nào mà vi khuẩn này lại có khả năng gây ra chứng
viêm hệ thống và hội chứng chuyển hóa? Để trả lời câu hỏi này, các nhà nghiên cứu
tập trung vào hệ vi sinh vật đường ruột, mạng lưới vi khuẩn hiện diện trong ruột
và các sinh vật này cùng tồn tại cộng sinh. Điều thú vị là các nhà nghiên cứu
đã phát hiện ra rằng ở những con chuột được sử dụng vi khuẩn Porphyromonas
gingivalis, hệ vi sinh vật đường ruột đã bị thay đổi đáng kể, có thể làm giảm độ
nhạy insulin.
Giáo sư Sayaka Katagiri cho biết: “Đây là những kết quả nổi
bật cung cấp cơ chế mối liên hệ giữa nhiễm vi khuẩn nha chu Porphyromonas
gingivalis và sự phát triển của hội chứng chuyển hóa và rối loạn chức năng trao
đổi chất trong cơ xương.
Đây là một nghiên cứu y học quan trọng để đánh giá chính xác
mức độ tiềm ẩn nguy hại của bệnh viêm nha chu để từ đó chúng ta ý thức hơn
trong công tác phòng bệnh
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Digital Workplace Software
A digital workplace is a cloud based work platform that lets businesses move work to the virtual space.
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Campaign Management Software
A campaign management system (CMS) is a software solution designed to handle the various components of a marketing campaign.
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